Drug interactions
Butabarbital + Tolterodine
Severity: Minor
Butabarbital and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is an enzyme inducer and may lower tolterodine exposure by increasing its CYP3A4 metabolism. The effect on symptom control is likely small in most patients, as the CYP2D6 pathway predominates.
What this interaction means in plain words
Butabarbital and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 by barbiturates increases tolterodine clearance.
What to do
Monitor for reduced response to tolterodine and titrate the dose if needed. No routine adjustment is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Butabarbital with Tolterodine?
MediHelp rates the interaction as minor. Butabarbital and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butabarbital is an enzyme inducer and may lower tolterodine exposure by increasing its CYP3A4 metabolism. The effect on symptom control is likely small in most patients, as the CYP2D6 pathway predominates.
How serious is the interaction between Butabarbital and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to tolterodine and titrate the dose if needed. No routine adjustment is required.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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