Drug interactions
Butalbital + Cyclosporin
Severity: Moderate
Butalbital and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce CYP3A4 and reduce cyclosporine exposure. Intermittent use has a smaller effect, but regular use can risk loss of immunosuppression.
What this interaction means in plain words
Butalbital and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Butalbital induces CYP3A4, increasing cyclosporine metabolism.
What to do
Monitor cyclosporine trough levels if butalbital is used regularly, and adjust the dose accordingly. Prefer a non-barbiturate analgesic for headache.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Butalbital with Cyclosporin?
MediHelp rates the interaction as moderate. Butalbital and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that may induce CYP3A4 and reduce cyclosporine exposure. Intermittent use has a smaller effect, but regular use can risk loss of immunosuppression.
How serious is the interaction between Butalbital and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels if butalbital is used regularly, and adjust the dose accordingly. Prefer a non-barbiturate analgesic for headache.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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