Drug interactions
Butalbital + Deflazacort
Severity: Moderate
Butalbital and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that induces CYP3A4 and can reduce exposure to deflazacort's active metabolite. Reduced steroid efficacy is possible.
What this interaction means in plain words
Butalbital and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Butalbital induces CYP3A4, increasing metabolism of deflazacort's active metabolite.
What to do
Avoid regular use together where possible; if needed occasionally, monitor clinical response. Consider a non-barbiturate headache therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Butalbital with Deflazacort?
MediHelp rates the interaction as moderate. Butalbital and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that induces CYP3A4 and can reduce exposure to deflazacort's active metabolite. Reduced steroid efficacy is possible.
How serious is the interaction between Butalbital and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use together where possible; if needed occasionally, monitor clinical response. Consider a non-barbiturate headache therapy.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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