Drug interactions
Butalbital + Dipyridamole
Severity: Minor
Butalbital and Dipyridamole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital, a barbiturate, may induce hepatic enzymes and lower dipyridamole exposure, potentially reducing its antiplatelet effect. The clinical significance is uncertain and not well documented.
What this interaction means in plain words
Butalbital and Dipyridamole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated hepatic enzyme induction may increase dipyridamole metabolism.
What to do
No routine change is needed; monitor for reduced antithrombotic effect if used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Frequently asked questions
Can I take Butalbital with Dipyridamole?
MediHelp rates the interaction as minor. Butalbital and Dipyridamole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital, a barbiturate, may induce hepatic enzymes and lower dipyridamole exposure, potentially reducing its antiplatelet effect. The clinical significance is uncertain and not well documented.
How serious is the interaction between Butalbital and Dipyridamole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for reduced antithrombotic effect if used long term.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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