Drug interactions
Butalbital + Erlotinib
Severity: Moderate
Butalbital and Erlotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate with enzyme-inducing properties that may increase erlotinib metabolism. This could lower erlotinib exposure and reduce efficacy, although the effect is likely smaller with intermittent use.
What this interaction means in plain words
Butalbital and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-related induction of CYP3A4 may accelerate erlotinib clearance.
What to do
Avoid regular use of butalbital-containing products where an alternative analgesic is available. If used, monitor for reduced erlotinib efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Butalbital with Erlotinib?
MediHelp rates the interaction as moderate. Butalbital and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate with enzyme-inducing properties that may increase erlotinib metabolism. This could lower erlotinib exposure and reduce efficacy, although the effect is likely smaller with intermittent use.
How serious is the interaction between Butalbital and Erlotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use of butalbital-containing products where an alternative analgesic is available. If used, monitor for reduced erlotinib efficacy.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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