Drug interactions
Butalbital + Fesoterodine
Severity: Moderate
Butalbital and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce CYP3A4 and lower exposure to the active metabolite of fesoterodine. Reduced control of overactive bladder symptoms may result.
What this interaction means in plain words
Butalbital and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 increases metabolism of fesoterodine's active metabolite.
What to do
Monitor for reduced efficacy and adjust the fesoterodine dose within labeled limits if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Butalbital with Fesoterodine?
MediHelp rates the interaction as moderate. Butalbital and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that may induce CYP3A4 and lower exposure to the active metabolite of fesoterodine. Reduced control of overactive bladder symptoms may result.
How serious is the interaction between Butalbital and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy and adjust the fesoterodine dose within labeled limits if needed.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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