Drug interactions
Butalbital + Flurbiprofen
Severity: Minor
Butalbital and Flurbiprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital may modestly reduce flurbiprofen levels through enzyme induction. Any loss of anti-inflammatory or analgesic effect is likely small.
What this interaction means in plain words
Butalbital and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated induction of hepatic CYP2C9 may increase flurbiprofen clearance.
What to do
No routine adjustment is needed; reassess flurbiprofen efficacy if butalbital is used frequently or long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Butalbital with Flurbiprofen?
MediHelp rates the interaction as minor. Butalbital and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital may modestly reduce flurbiprofen levels through enzyme induction. Any loss of anti-inflammatory or analgesic effect is likely small.
How serious is the interaction between Butalbital and Flurbiprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess flurbiprofen efficacy if butalbital is used frequently or long term.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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