Drug interactions
Butalbital + Ibuprofen
Severity: Minor
Butalbital and Ibuprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate with enzyme-inducing potential, which could modestly increase CYP2C9-mediated clearance of ibuprofen. The effect is expected to be small, particularly with short-term use.
What this interaction means in plain words
Butalbital and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated induction of CYP2C9 may increase ibuprofen metabolism.
What to do
No routine adjustment is needed; reassess analgesic response if the combination is used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Butalbital with Ibuprofen?
MediHelp rates the interaction as minor. Butalbital and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate with enzyme-inducing potential, which could modestly increase CYP2C9-mediated clearance of ibuprofen. The effect is expected to be small, particularly with short-term use.
How serious is the interaction between Butalbital and Ibuprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess analgesic response if the combination is used long term.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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