Drug interactions
Butalbital + Ketoconazole
Severity: Minor
Butalbital and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate and may induce CYP3A4, lowering ketoconazole levels. Clinical impact is likely small with intermittent use but may matter with frequent dosing.
What this interaction means in plain words
Butalbital and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated CYP3A4 induction increases ketoconazole metabolism.
What to do
Monitor antifungal response if butalbital is used regularly. Consider an alternative if efficacy is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Butalbital with Ketoconazole?
MediHelp rates the interaction as minor. Butalbital and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate and may induce CYP3A4, lowering ketoconazole levels. Clinical impact is likely small with intermittent use but may matter with frequent dosing.
How serious is the interaction between Butalbital and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antifungal response if butalbital is used regularly. Consider an alternative if efficacy is inadequate.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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