Drug interactions
Butalbital + Metformin-repaglinide
Severity: Moderate
Butalbital and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate and may induce hepatic enzymes that metabolize repaglinide. This could lower repaglinide levels and weaken glucose control, though the effect is probably modest with intermittent use.
What this interaction means in plain words
Butalbital and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of CYP3A4 and CYP2C8 increases repaglinide clearance.
What to do
Monitor blood glucose with regular butalbital use and adjust the repaglinide dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Butalbital with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Butalbital and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate and may induce hepatic enzymes that metabolize repaglinide. This could lower repaglinide levels and weaken glucose control, though the effect is probably modest with intermittent use.
How serious is the interaction between Butalbital and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose with regular butalbital use and adjust the repaglinide dose if control worsens.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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