Drug interactions
Butalbital + Nifedipine
Severity: Minor
Butalbital and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate with possible weak CYP3A4 induction and could modestly lower nifedipine exposure with repeated use. Intermittent use is unlikely to matter clinically.
What this interaction means in plain words
Butalbital and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated CYP3A4 induction may increase nifedipine metabolism.
What to do
Monitor blood pressure if butalbital is used frequently and adjust nifedipine if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Butalbital with Nifedipine?
MediHelp rates the interaction as minor. Butalbital and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate with possible weak CYP3A4 induction and could modestly lower nifedipine exposure with repeated use. Intermittent use is unlikely to matter clinically.
How serious is the interaction between Butalbital and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if butalbital is used frequently and adjust nifedipine if control worsens.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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