Drug interactions
Butalbital + Pazopanib
Severity: Moderate
Butalbital and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital, a barbiturate, can induce CYP3A4 and may lower pazopanib exposure. Occasional use likely has small effect but regular use could compromise efficacy.
What this interaction means in plain words
Butalbital and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated CYP3A4 induction increases pazopanib metabolism.
What to do
Avoid regular butalbital use where possible and choose a non-inducing headache therapy. Monitor tumor response if it is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Butalbital with Pazopanib?
MediHelp rates the interaction as moderate. Butalbital and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital, a barbiturate, can induce CYP3A4 and may lower pazopanib exposure. Occasional use likely has small effect but regular use could compromise efficacy.
How serious is the interaction between Butalbital and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular butalbital use where possible and choose a non-inducing headache therapy. Monitor tumor response if it is needed.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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