Drug interactions
Butalbital + Sorafenib
Severity: Moderate
Butalbital and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate with enzyme-inducing properties and may reduce sorafenib exposure. This could compromise anticancer efficacy, although occasional analgesic use is unlikely to matter much.
What this interaction means in plain words
Butalbital and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Butalbital induces CYP3A4 and possibly glucuronidation, increasing sorafenib clearance.
What to do
Prefer a non-inducing analgesic for headaches where possible. If butalbital is used regularly, monitor for reduced tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Frequently asked questions
Can I take Butalbital with Sorafenib?
MediHelp rates the interaction as moderate. Butalbital and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate with enzyme-inducing properties and may reduce sorafenib exposure. This could compromise anticancer efficacy, although occasional analgesic use is unlikely to matter much.
How serious is the interaction between Butalbital and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing analgesic for headaches where possible. If butalbital is used regularly, monitor for reduced tumor response.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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