Drug interactions
Butalbital + Sunitinib
Severity: Moderate
Butalbital and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce CYP3A4 and reduce sunitinib exposure. Occasional use is likely of little consequence, but regular use could reduce efficacy.
What this interaction means in plain words
Butalbital and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by butalbital increases sunitinib metabolism.
What to do
Avoid regular butalbital use where an alternative analgesic is available. If regular use is needed, monitor tumor response and consider a sunitinib dose adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Butalbital with Sunitinib?
MediHelp rates the interaction as moderate. Butalbital and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that may induce CYP3A4 and reduce sunitinib exposure. Occasional use is likely of little consequence, but regular use could reduce efficacy.
How serious is the interaction between Butalbital and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular butalbital use where an alternative analgesic is available. If regular use is needed, monitor tumor response and consider a sunitinib dose adjustment.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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