Drug interactions
Butalbital + Tamoxifen
Severity: Moderate
Butalbital and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates such as butalbital can induce CYP3A4 and may reduce tamoxifen and endoxifen concentrations. Intermittent use makes the effect modest, but regular use could lessen tamoxifen efficacy.
What this interaction means in plain words
Butalbital and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by butalbital increases tamoxifen clearance.
What to do
Avoid regular use of butalbital with tamoxifen and choose non-inducing analgesics where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Frequently asked questions
Can I take Butalbital with Tamoxifen?
MediHelp rates the interaction as moderate. Butalbital and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates such as butalbital can induce CYP3A4 and may reduce tamoxifen and endoxifen concentrations. Intermittent use makes the effect modest, but regular use could lessen tamoxifen efficacy.
How serious is the interaction between Butalbital and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use of butalbital with tamoxifen and choose non-inducing analgesics where possible.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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