Drug interactions
Butalbital + Timolol
Severity: Moderate
Butalbital and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that induces hepatic enzymes and may lower timolol concentrations. Reduced beta-blockade could weaken blood pressure and heart rate control.
What this interaction means in plain words
Butalbital and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of hepatic metabolism increases timolol clearance.
What to do
Monitor heart rate and blood pressure, particularly with frequent butalbital use, and adjust the timolol dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Butalbital with Timolol?
MediHelp rates the interaction as moderate. Butalbital and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that induces hepatic enzymes and may lower timolol concentrations. Reduced beta-blockade could weaken blood pressure and heart rate control.
How serious is the interaction between Butalbital and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, particularly with frequent butalbital use, and adjust the timolol dose if control worsens.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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