Drug interactions
Butalbital + Tolterodine
Severity: Minor
Butalbital and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce CYP3A4 and slightly reduce tolterodine exposure. Clinical impact is likely limited in most patients.
What this interaction means in plain words
Butalbital and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated CYP3A4 induction increases tolterodine metabolism.
What to do
Watch for reduced bladder symptom control with prolonged combined use. Adjust tolterodine dosing according to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Butalbital with Tolterodine?
MediHelp rates the interaction as minor. Butalbital and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate that may induce CYP3A4 and slightly reduce tolterodine exposure. Clinical impact is likely limited in most patients.
How serious is the interaction between Butalbital and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for reduced bladder symptom control with prolonged combined use. Adjust tolterodine dosing according to response.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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