Drug interactions
Butalbital + Tolvaptan
Severity: Moderate
Butalbital and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce CYP3A4 and reduce tolvaptan exposure. This can lead to reduced efficacy in raising serum sodium or slowing disease progression.
What this interaction means in plain words
Butalbital and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated CYP3A4 induction increases tolvaptan clearance.
What to do
Monitor serum sodium and therapeutic response, and increase the tolvaptan dose if needed. Prefer non-barbiturate analgesics when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Butalbital with Tolvaptan?
MediHelp rates the interaction as moderate. Butalbital and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that may induce CYP3A4 and reduce tolvaptan exposure. This can lead to reduced efficacy in raising serum sodium or slowing disease progression.
How serious is the interaction between Butalbital and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and therapeutic response, and increase the tolvaptan dose if needed. Prefer non-barbiturate analgesics when possible.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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