Drug interactions
Butalbital + Vincristine
Severity: Minor
Butalbital and Vincristine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce CYP3A4 and lower vincristine concentrations. The effect is likely modest with intermittent use.
What this interaction means in plain words
Butalbital and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Butalbital induces CYP3A4, increasing vincristine metabolism.
What to do
Monitor for reduced vincristine efficacy if butalbital is used regularly. Prefer an alternative analgesic for frequent use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Butalbital with Vincristine?
MediHelp rates the interaction as minor. Butalbital and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate that may induce CYP3A4 and lower vincristine concentrations. The effect is likely modest with intermittent use.
How serious is the interaction between Butalbital and Vincristine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced vincristine efficacy if butalbital is used regularly. Prefer an alternative analgesic for frequent use.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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