Drug interactions
Atazanavir + Vincristine
Severity: Major
Atazanavir and Vincristine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and may increase vincristine exposure, raising the risk of neurotoxicity and constipation or ileus. Toxicity is a concern with ritonavir- or cobicistat-boosted regimens in particular.
What this interaction means in plain words
Atazanavir and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Vincristine belongs to Oncology.
Why it happens
Atazanavir inhibits CYP3A4, reducing vincristine clearance.
What to do
Monitor for neuropathy, constipation and myelosuppression, and consider an alternative antiretroviral without CYP3A inhibition. Reduce the vincristine dose if toxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
- Cobicistat + Vincristine Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Vincristine?
MediHelp rates the interaction as major. Atazanavir and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir inhibits CYP3A4 and may increase vincristine exposure, raising the risk of neurotoxicity and constipation or ileus. Toxicity is a concern with ritonavir- or cobicistat-boosted regimens in particular.
How serious is the interaction between Atazanavir and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, constipation and myelosuppression, and consider an alternative antiretroviral without CYP3A inhibition. Reduce the vincristine dose if toxicity develops.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Ceritinib. The full list is on the Vincristine page.
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