Drug interactions
Butorphanol + Lofexidine
Severity: Moderate
Butorphanol and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is an alpha-2 agonist that causes sedation, hypotension and bradycardia, and an opioid can add to these effects. Together they may cause excessive drowsiness, dizziness and fainting.
What this interaction means in plain words
Butorphanol and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Lofexidine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects from alpha-2 adrenergic agonism and opioid receptor activity.
What to do
Monitor blood pressure, heart rate and sedation, and reduce doses if symptomatic hypotension or oversedation occurs. Advise patients to rise slowly and avoid driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Butorphanol with Lofexidine?
MediHelp rates the interaction as moderate. Butorphanol and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine is an alpha-2 agonist that causes sedation, hypotension and bradycardia, and an opioid can add to these effects. Together they may cause excessive drowsiness, dizziness and fainting.
How serious is the interaction between Butorphanol and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation, and reduce doses if symptomatic hypotension or oversedation occurs. Advise patients to rise slowly and avoid driving.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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