Drug interactions
Butorphanol + Rasagiline
Severity: Moderate
Butorphanol and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is an irreversible MAO-B inhibitor, and opioid analgesics given with MAO inhibitors may cause additive sedation, dizziness and hypotension. Serotonin toxicity has been reported with some opioids and MAO inhibitors, although butorphanol is less serotonergic.
What this interaction means in plain words
Butorphanol and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition may potentiate opioid CNS depression and hypotension and may add serotonergic effects; the mechanism for butorphanol is not well defined.
What to do
Start butorphanol at a reduced dose and titrate carefully, monitoring sedation, blood pressure and signs of serotonin toxicity. Consider a non-serotonergic alternative analgesic where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Butorphanol with Rasagiline?
MediHelp rates the interaction as moderate. Butorphanol and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is an irreversible MAO-B inhibitor, and opioid analgesics given with MAO inhibitors may cause additive sedation, dizziness and hypotension. Serotonin toxicity has been reported with some opioids and MAO inhibitors, although butorphanol is less serotonergic.
How serious is the interaction between Butorphanol and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start butorphanol at a reduced dose and titrate carefully, monitoring sedation, blood pressure and signs of serotonin toxicity. Consider a non-serotonergic alternative analgesic where feasible.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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