Drug interactions
Cabergoline + Efavirenz
Severity: Moderate
Cabergoline and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may alter cabergoline exposure through effects on CYP3A4, and higher levels could cause hypotension or ergot-related vasospasm. The interaction is predicted rather than well documented.
What this interaction means in plain words
Cabergoline and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabergoline belongs to Endocrine; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz modulates CYP3A4 activity, which may change cabergoline metabolism; the direction and extent are uncertain.
What to do
Monitor for ergot-related adverse effects and for changes in prolactin control. Adjust the cabergoline dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Cabergoline
Frequently asked questions
Can I take Cabergoline with Efavirenz?
MediHelp rates the interaction as moderate. Cabergoline and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may alter cabergoline exposure through effects on CYP3A4, and higher levels could cause hypotension or ergot-related vasospasm. The interaction is predicted rather than well documented.
How serious is the interaction between Cabergoline and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ergot-related adverse effects and for changes in prolactin control. Adjust the cabergoline dose according to response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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