Drug interactions
Cabergoline + Methyldopa
Severity: Moderate
Cabergoline and Methyldopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabergoline is a dopamine agonist, while methyldopa is converted to false transmitters that reduce catecholamine function and can raise prolactin. Methyldopa may therefore oppose cabergoline's prolactin-lowering effect, and both may add to hypotension.
What this interaction means in plain words
Cabergoline and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabergoline belongs to Endocrine; Methyldopa belongs to Cardiovascular.
Why it happens
Methyldopa's false neurotransmitter and central dopamine-lowering effect antagonizes dopamine agonism; both can lower blood pressure.
What to do
Monitor prolactin levels and symptoms in hyperprolactinemia, and check blood pressure. Consider a different antihypertensive if prolactin control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methyldopa
- Methyldopa + Tranylcypromine Contraindicated
- Iobenguane i + Methyldopa Major
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
Other interactions of Cabergoline
Frequently asked questions
Can I take Cabergoline with Methyldopa?
MediHelp rates the interaction as moderate. Cabergoline and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cabergoline is a dopamine agonist, while methyldopa is converted to false transmitters that reduce catecholamine function and can raise prolactin. Methyldopa may therefore oppose cabergoline's prolactin-lowering effect, and both may add to hypotension.
How serious is the interaction between Cabergoline and Methyldopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor prolactin levels and symptoms in hyperprolactinemia, and check blood pressure. Consider a different antihypertensive if prolactin control is lost.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Iobenguane i, Lofexidine. The full list is on the Methyldopa page.
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