Drug interactions
Cabotegravir + Lamivudine
Severity: Moderate
Cabotegravir and Lamivudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral or injectable cabotegravir with rilpivirine is a complete regimen for HIV-1 and is not intended to be combined with other antiretrovirals. Adding lamivudine is generally unnecessary and is not an established regimen. There is no clear pharmacokinetic interaction.
What this interaction means in plain words
Cabotegravir and Lamivudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabotegravir belongs to Anti Virals; Lamivudine belongs to Anti Virals.
Why it happens
No established pharmacokinetic interaction; the concern is use outside the approved complete regimen.
What to do
Do not add lamivudine to cabotegravir plus rilpivirine unless an HIV specialist directs it. Choose one complete regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamivudine
Other interactions of Cabotegravir
- Apalutamide + Cabotegravir Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Cabotegravir + Oxcarbazepine Contraindicated
- Cabotegravir + Phenobarbitone Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Cabotegravir + Rifabutin Contraindicated
Frequently asked questions
Can I take Cabotegravir with Lamivudine?
MediHelp rates the interaction as moderate. Cabotegravir and Lamivudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral or injectable cabotegravir with rilpivirine is a complete regimen for HIV-1 and is not intended to be combined with other antiretrovirals. Adding lamivudine is generally unnecessary and is not an established regimen. There is no clear pharmacokinetic interaction.
How serious is the interaction between Cabotegravir and Lamivudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not add lamivudine to cabotegravir plus rilpivirine unless an HIV specialist directs it. Choose one complete regimen.
What other medicines interact with Lamivudine?
MediHelp also lists interactions of Lamivudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Atidarsagene autotemcel, Betibeglogene autotemcel. The full list is on the Lamivudine page.
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