Drug interactions
Apalutamide + Cabotegravir
Severity: Contraindicated
Apalutamide and Cabotegravir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces UGT1A1 and other enzymes, lowering cabotegravir concentrations, particularly with long-acting injectable cabotegravir. This risks loss of virologic response and integrase resistance.
What this interaction means in plain words
Apalutamide and Cabotegravir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Cabotegravir belongs to Anti Virals.
Why it happens
Apalutamide induces UGT1A1 (and UGT1A9), increasing cabotegravir glucuronidation.
What to do
Do not coadminister; use an alternative antiandrogen or antiretroviral. Monitor HIV RNA if exposure occurred.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Apalutamide
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
Other interactions of Cabotegravir
- Cabotegravir + Carbamazepine Contraindicated
- Cabotegravir + Oxcarbazepine Contraindicated
- Cabotegravir + Phenobarbitone Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Cabotegravir + Rifabutin Contraindicated
- Cabotegravir + Rifampicin Contraindicated
Frequently asked questions
Can I take Apalutamide with Cabotegravir?
MediHelp rates the interaction as contraindicated. Apalutamide and Cabotegravir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide induces UGT1A1 and other enzymes, lowering cabotegravir concentrations, particularly with long-acting injectable cabotegravir. This risks loss of virologic response and integrase resistance.
How serious is the interaction between Apalutamide and Cabotegravir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antiandrogen or antiretroviral. Monitor HIV RNA if exposure occurred.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cobicistat, Doravirine, Elbasvir / grazoprevir. The full list is on the Apalutamide page.
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