Drug interactions
Cabotegravir + Lamotrigine
Severity: Minor
Cabotegravir and Lamotrigine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lamotrigine is a weak UGT inducer and is not recognised as a strong UGT1A1 inducer, so a clinically meaningful drop in cabotegravir exposure is unlikely. The contraindication applies to strong inducers such as rifampin and certain older anticonvulsants.
What this interaction means in plain words
Cabotegravir and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cabotegravir belongs to Anti Virals; Lamotrigine belongs to Central Nervous System.
Why it happens
Lamotrigine has only weak induction of UGT enzymes, with limited effect on cabotegravir clearance.
What to do
No dose change is generally needed. Monitor HIV viral load as routinely scheduled.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lamotrigine
Other interactions of Cabotegravir
- Apalutamide + Cabotegravir Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Cabotegravir + Oxcarbazepine Contraindicated
- Cabotegravir + Phenobarbitone Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Cabotegravir + Rifabutin Contraindicated
Frequently asked questions
Can I take Cabotegravir with Lamotrigine?
MediHelp rates the interaction as minor. Cabotegravir and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lamotrigine is a weak UGT inducer and is not recognised as a strong UGT1A1 inducer, so a clinically meaningful drop in cabotegravir exposure is unlikely. The contraindication applies to strong inducers such as rifampin and certain older anticonvulsants.
How serious is the interaction between Cabotegravir and Lamotrigine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor HIV viral load as routinely scheduled.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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