Drug interactions
Cabotegravir + Tenofovir disoproxil
Severity: Moderate
Cabotegravir and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabotegravir with rilpivirine is a complete regimen for virologically suppressed HIV-1 and is not intended to be combined with other antiretrovirals. However, cabotegravir is also used for PrEP or oral lead-in and there is no pharmacokinetic interaction with tenofovir.
What this interaction means in plain words
Cabotegravir and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
No pharmacokinetic interaction; the concern is therapeutic duplication within a complete regimen.
What to do
Do not add tenofovir to the cabotegravir/rilpivirine treatment regimen unless directed by an HIV specialist. Cabotegravir can be used with tenofovir-based oral regimens when clinically intended.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabotegravir
- Apalutamide + Cabotegravir Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Cabotegravir + Oxcarbazepine Contraindicated
- Cabotegravir + Phenobarbitone Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Cabotegravir + Rifabutin Contraindicated
Frequently asked questions
Can I take Cabotegravir with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Cabotegravir and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cabotegravir with rilpivirine is a complete regimen for virologically suppressed HIV-1 and is not intended to be combined with other antiretrovirals. However, cabotegravir is also used for PrEP or oral lead-in and there is no pharmacokinetic interaction with tenofovir.
How serious is the interaction between Cabotegravir and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not add tenofovir to the cabotegravir/rilpivirine treatment regimen unless directed by an HIV specialist. Cabotegravir can be used with tenofovir-based oral regimens when clinically intended.
What other medicines interact with Cabotegravir?
MediHelp also lists interactions of Cabotegravir with, for example, Apalutamide, Carbamazepine, Oxcarbazepine. The full list is on the Cabotegravir page.
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