Drug interactions
Cabozantinib + Cyclosporin
Severity: Moderate
Cabozantinib and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase cabozantinib exposure by inhibiting CYP3A4, increasing the risk of adverse effects such as diarrhea, hypertension, hand-foot syndrome and bleeding. The effect of moderate inhibition is likely modest.
What this interaction means in plain words
Cabozantinib and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Cyclosporin belongs to Miscellaneous.
Why it happens
Cyclosporine inhibits CYP3A4, reducing cabozantinib clearance.
What to do
Monitor for cabozantinib toxicity, especially hypertension and gastrointestinal effects, and reduce the dose if adverse reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Cyclosporin?
MediHelp rates the interaction as moderate. Cabozantinib and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may increase cabozantinib exposure by inhibiting CYP3A4, increasing the risk of adverse effects such as diarrhea, hypertension, hand-foot syndrome and bleeding. The effect of moderate inhibition is likely modest.
How serious is the interaction between Cabozantinib and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cabozantinib toxicity, especially hypertension and gastrointestinal effects, and reduce the dose if adverse reactions occur.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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