Drug interactions
Cabozantinib + Erythromycin
Severity: Moderate
Cabozantinib and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a moderate CYP3A4 inhibitor and may increase cabozantinib concentrations. Higher exposure may increase toxicities such as diarrhea, hypertension, hemorrhage and hand-foot syndrome.
What this interaction means in plain words
Cabozantinib and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated cabozantinib metabolism.
What to do
Monitor for cabozantinib adverse effects and reduce the dose if toxicity develops. Consider a non-CYP3A4-inhibiting antibiotic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Erythromycin?
MediHelp rates the interaction as moderate. Cabozantinib and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin is a moderate CYP3A4 inhibitor and may increase cabozantinib concentrations. Higher exposure may increase toxicities such as diarrhea, hypertension, hemorrhage and hand-foot syndrome.
How serious is the interaction between Cabozantinib and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cabozantinib adverse effects and reduce the dose if toxicity develops. Consider a non-CYP3A4-inhibiting antibiotic where possible.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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