Drug interactions
Cabozantinib + Lorlatinib
Severity: Moderate
Cabozantinib and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4, which can reduce cabozantinib plasma concentrations and potentially lessen antitumor efficacy. The effect is predicted from the inducing activity of lorlatinib.
What this interaction means in plain words
Cabozantinib and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, accelerating the metabolism of cabozantinib.
What to do
Monitor for reduced response to cabozantinib. Per cabozantinib labeling for strong CYP3A4 inducers, a dose increase may be considered, with dose reduction after the inducer is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Lorlatinib?
MediHelp rates the interaction as moderate. Cabozantinib and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4, which can reduce cabozantinib plasma concentrations and potentially lessen antitumor efficacy. The effect is predicted from the inducing activity of lorlatinib.
How serious is the interaction between Cabozantinib and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to cabozantinib. Per cabozantinib labeling for strong CYP3A4 inducers, a dose increase may be considered, with dose reduction after the inducer is stopped.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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