Drug interactions
Cabozantinib + Oxcarbazepine
Severity: Moderate
Cabozantinib and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may lower cabozantinib exposure and reduce antitumor efficacy, though less than strong inducers.
What this interaction means in plain words
Cabozantinib and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Oxcarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction by oxcarbazepine increases cabozantinib metabolism.
What to do
Prefer a non-inducing anticonvulsant. If coadministered, monitor response and consider a cabozantinib dose increase per labeling for inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Oxcarbazepine?
MediHelp rates the interaction as moderate. Cabozantinib and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may lower cabozantinib exposure and reduce antitumor efficacy, though less than strong inducers.
How serious is the interaction between Cabozantinib and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing anticonvulsant. If coadministered, monitor response and consider a cabozantinib dose increase per labeling for inducers.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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