Drug interactions
Calcium chloride + Chlorthalidone
Severity: Moderate
Calcium chloride and Chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone lowers urinary calcium loss, so administered calcium chloride may produce higher serum calcium than expected. Risk is greatest with repeated or large doses and in patients with reduced kidney function.
What this interaction means in plain words
Calcium chloride and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chlorthalidone increases distal tubular calcium reabsorption, reducing renal calcium clearance.
What to do
Check serum calcium when calcium chloride is given repeatedly alongside chlorthalidone. Adjust the calcium dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Frequently asked questions
Can I take Calcium chloride with Chlorthalidone?
MediHelp rates the interaction as moderate. Calcium chloride and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone lowers urinary calcium loss, so administered calcium chloride may produce higher serum calcium than expected. Risk is greatest with repeated or large doses and in patients with reduced kidney function.
How serious is the interaction between Calcium chloride and Chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium when calcium chloride is given repeatedly alongside chlorthalidone. Adjust the calcium dose if levels rise.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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