Drug interactions
Calcium chloride + Ofloxacin
Severity: Moderate
Calcium chloride and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium salts can bind ofloxacin in the gut and reduce how much antibiotic is absorbed. This can lead to subtherapeutic concentrations and treatment failure.
What this interaction means in plain words
Calcium chloride and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of ofloxacin by calcium ions in the gastrointestinal tract reduces its absorption.
What to do
Separate oral ofloxacin from oral calcium by at least 2 hours, giving ofloxacin first. This does not apply to intravenous calcium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium chloride and Ofloxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Calcium chloride with Ofloxacin?
MediHelp rates the interaction as moderate. Calcium chloride and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium salts can bind ofloxacin in the gut and reduce how much antibiotic is absorbed. This can lead to subtherapeutic concentrations and treatment failure.
How serious is the interaction between Calcium chloride and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral ofloxacin from oral calcium by at least 2 hours, giving ofloxacin first. This does not apply to intravenous calcium.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
