Drug interactions
Calcium citrate + Chlorthalidone
Severity: Moderate
Calcium citrate and Chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone decreases renal calcium excretion, which can lead to hypercalcemia when calcium citrate supplements are taken regularly. Patients on high supplement doses, with vitamin D or with renal impairment are at greater risk.
What this interaction means in plain words
Calcium citrate and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chlorthalidone enhances distal tubular calcium reabsorption, reducing renal calcium clearance.
What to do
Monitor serum calcium at baseline and periodically during combined use. Lower the supplement dose if calcium is elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium citrate and Chlorthalidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Calcium citrate with Chlorthalidone?
MediHelp rates the interaction as moderate. Calcium citrate and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone decreases renal calcium excretion, which can lead to hypercalcemia when calcium citrate supplements are taken regularly. Patients on high supplement doses, with vitamin D or with renal impairment are at greater risk.
How serious is the interaction between Calcium citrate and Chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium at baseline and periodically during combined use. Lower the supplement dose if calcium is elevated.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
