Drug interactions
Calcium citrate + Hydrochlorothiazide-valsartan
Severity: Moderate
Calcium citrate and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides reduce urinary calcium excretion, so calcium supplements can raise serum calcium. Hypercalcemia is more likely with high doses, vitamin D co-use or reduced renal function.
What this interaction means in plain words
Calcium citrate and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-enhanced renal calcium reabsorption in the distal tubule adds to calcium intake.
What to do
Check serum calcium periodically, and lower the supplement dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Calcium citrate with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Calcium citrate and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion, so calcium supplements can raise serum calcium. Hypercalcemia is more likely with high doses, vitamin D co-use or reduced renal function.
How serious is the interaction between Calcium citrate and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium periodically, and lower the supplement dose if levels rise.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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