Drug interactions
Calcium citrate + Nifedipine
Severity: Minor
Calcium citrate and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium salts given orally can in theory oppose calcium channel blockers, but oral calcium at usual doses rarely reduces the antihypertensive effect of nifedipine. Reversal is mainly seen with intravenous calcium in overdose or toxicity.
What this interaction means in plain words
Calcium citrate and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Increased extracellular calcium may theoretically counteract calcium channel blockade.
What to do
No routine action is needed; check blood pressure if high calcium doses are used or hypercalcemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Calcium citrate with Nifedipine?
MediHelp rates the interaction as minor. Calcium citrate and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium salts given orally can in theory oppose calcium channel blockers, but oral calcium at usual doses rarely reduces the antihypertensive effect of nifedipine. Reversal is mainly seen with intravenous calcium in overdose or toxicity.
How serious is the interaction between Calcium citrate and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check blood pressure if high calcium doses are used or hypercalcemia develops.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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