Drug interactions
Calcium citrate + Ofloxacin
Severity: Moderate
Calcium citrate and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium citrate supplements can bind oral ofloxacin in the gut and lower its absorption. The result may be reduced antibacterial efficacy.
What this interaction means in plain words
Calcium citrate and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of ofloxacin by calcium ions in the gastrointestinal tract reduces its absorption.
What to do
Take ofloxacin at least 2 hours before or after calcium citrate. Monitor clinical response to the antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Calcium citrate with Ofloxacin?
MediHelp rates the interaction as moderate. Calcium citrate and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium citrate supplements can bind oral ofloxacin in the gut and lower its absorption. The result may be reduced antibacterial efficacy.
How serious is the interaction between Calcium citrate and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take ofloxacin at least 2 hours before or after calcium citrate. Monitor clinical response to the antibiotic.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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