Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Cyclizine
Severity: Major
Calcium / magnesium / potassium / sodium oxybates and Cyclizine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybate salts cause marked CNS and respiratory depression, and cyclizine is a sedating antihistamine. Combined use can result in profound sedation, respiratory depression, coma and death.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Cyclizine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through pharmacodynamic synergism.
What to do
Avoid concurrent use where alternatives exist; if unavoidable, use the lowest effective doses and monitor closely for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclizine
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
- Amantadine + Cyclizine Moderate
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Cyclizine?
MediHelp rates the interaction as major. Calcium / magnesium / potassium / sodium oxybates and Cyclizine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybate salts cause marked CNS and respiratory depression, and cyclizine is a sedating antihistamine. Combined use can result in profound sedation, respiratory depression, coma and death.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Cyclizine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where alternatives exist; if unavoidable, use the lowest effective doses and monitor closely for sedation and respiratory depression.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Henbane, Sodium oxybate, Abobotulinumtoxina. The full list is on the Cyclizine page.
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