Drug interactions
Cyclizine + Henbane
Severity: Major
Cyclizine and Henbane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains the antimuscarinic alkaloids hyoscyamine and scopolamine. Together with cyclizine, anticholinergic effects such as dry mouth, tachycardia, urinary retention, confusion and hyperthermia can be intensified, with toxicity possible given the variable alkaloid content.
What this interaction means in plain words
Cyclizine and Henbane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid using henbane with cyclizine. If exposure has occurred, monitor for anticholinergic toxicity and treat supportively.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
- Amantadine + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Henbane?
MediHelp rates the interaction as major. Cyclizine and Henbane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Henbane contains the antimuscarinic alkaloids hyoscyamine and scopolamine. Together with cyclizine, anticholinergic effects such as dry mouth, tachycardia, urinary retention, confusion and hyperthermia can be intensified, with toxicity possible given the variable alkaloid content.
How serious is the interaction between Cyclizine and Henbane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using henbane with cyclizine. If exposure has occurred, monitor for anticholinergic toxicity and treat supportively.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Abobotulinumtoxina. The full list is on the Cyclizine page.
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