Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Cyclobenzaprine
Severity: Major
Calcium / magnesium / potassium / sodium oxybates and Cyclobenzaprine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybates are potent CNS depressants and cyclobenzaprine adds sedation. Together they may cause profound sedation, respiratory depression, coma and death.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Cyclobenzaprine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through pharmacodynamic synergy.
What to do
Avoid the combination when possible and select a non-sedating alternative. If unavoidable, use minimum doses and duration and monitor sedation and respiratory function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Cyclobenzaprine?
MediHelp rates the interaction as major. Calcium / magnesium / potassium / sodium oxybates and Cyclobenzaprine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybates are potent CNS depressants and cyclobenzaprine adds sedation. Together they may cause profound sedation, respiratory depression, coma and death.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Cyclobenzaprine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible and select a non-sedating alternative. If unavoidable, use minimum doses and duration and monitor sedation and respiratory function.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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