Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Ramelteon
Severity: Contraindicated
Calcium / magnesium / potassium / sodium oxybates and Ramelteon: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, and combined use may deepen CNS depression with a risk of respiratory depression, impaired arousal, and coma. Oxybate labeling advises against concomitant sedative hypnotics.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Ramelteon are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive CNS depression through pharmacodynamic synergism (melatonin receptor agonism plus GHB/GABA-B-mediated sedation).
What to do
Avoid combining; use an alternative approach to insomnia in patients on oxybate.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium / magnesium / potassium / sodium oxybates and Ramelteon, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ramelteon
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
- Amoxapine + Ramelteon Moderate
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Ramelteon?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Ramelteon are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents cause sedation, and combined use may deepen CNS depression with a risk of respiratory depression, impaired arousal, and coma. Oxybate labeling advises against concomitant sedative hypnotics.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Ramelteon?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; use an alternative approach to insomnia in patients on oxybate.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Fluvoxamine, Sodium oxybate, Alfentanil. The full list is on the Ramelteon page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
