Drug interactions
Amobarbital + Ramelteon
Severity: Moderate
Amobarbital and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and combined use may increase drowsiness and next-day impairment. Barbiturate induction may lower ramelteon concentrations and reduce its hypnotic effect.
What this interaction means in plain words
Amobarbital and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
Additive sedation plus induction of CYP1A2 and CYP3A4 by amobarbital increasing ramelteon metabolism.
What to do
Monitor sleep response and daytime sedation. Avoid use of both hypnotics together when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amoxapine + Ramelteon Moderate
Frequently asked questions
Can I take Amobarbital with Ramelteon?
MediHelp rates the interaction as moderate. Amobarbital and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and combined use may increase drowsiness and next-day impairment. Barbiturate induction may lower ramelteon concentrations and reduce its hypnotic effect.
How serious is the interaction between Amobarbital and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sleep response and daytime sedation. Avoid use of both hypnotics together when possible.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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