Drug interactions
Canagliflozin-metformin + Captopril
Severity: Moderate
Canagliflozin-metformin and Captopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Captopril can raise potassium, and canagliflozin may add to this effect in renal impairment. ACE inhibitors may also enhance glucose lowering, and any renal decline raises metformin accumulation risk.
What this interaction means in plain words
Canagliflozin-metformin and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Captopril belongs to Cardiovascular.
Why it happens
ACE inhibition lowers aldosterone and may improve insulin sensitivity, while renal effects can reduce metformin clearance.
What to do
Monitor potassium, renal function and blood glucose. Reassess metformin dose if eGFR declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Canagliflozin-metformin with Captopril?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Captopril can raise potassium, and canagliflozin may add to this effect in renal impairment. ACE inhibitors may also enhance glucose lowering, and any renal decline raises metformin accumulation risk.
How serious is the interaction between Canagliflozin-metformin and Captopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, renal function and blood glucose. Reassess metformin dose if eGFR declines.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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