Drug interactions
Canagliflozin-metformin + Cyclosporine
Severity: Moderate
Canagliflozin-metformin and Cyclosporine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can cause hyperkalemia and renal impairment. Renal impairment can raise the risk of metformin accumulation and lactic acidosis, and volume depletion with canagliflozin may worsen kidney function.
What this interaction means in plain words
Canagliflozin-metformin and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine causes renal vasoconstriction and reduced potassium excretion, with additive nephrotoxic and volume effects alongside canagliflozin.
What to do
Monitor serum potassium, creatinine and eGFR regularly. Reduce or stop metformin or canagliflozin if renal function declines significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Canagliflozin-metformin with Cyclosporine?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can cause hyperkalemia and renal impairment. Renal impairment can raise the risk of metformin accumulation and lactic acidosis, and volume depletion with canagliflozin may worsen kidney function.
How serious is the interaction between Canagliflozin-metformin and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and eGFR regularly. Reduce or stop metformin or canagliflozin if renal function declines significantly.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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