Drug interactions
Canagliflozin-metformin + Danazol
Severity: Moderate
Canagliflozin-metformin and Danazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can cause insulin resistance and impaired glucose tolerance, which may reduce glycemic control on canagliflozin-metformin. Its androgenic effects are the likely cause rather than an additive glucose-lowering action.
What this interaction means in plain words
Canagliflozin-metformin and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgenic activity of danazol reduces insulin sensitivity and glucose tolerance.
What to do
Monitor blood glucose when danazol is started or stopped and adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Canagliflozin-metformin with Danazol?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol can cause insulin resistance and impaired glucose tolerance, which may reduce glycemic control on canagliflozin-metformin. Its androgenic effects are the likely cause rather than an additive glucose-lowering action.
How serious is the interaction between Canagliflozin-metformin and Danazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when danazol is started or stopped and adjust antidiabetic doses as needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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