Drug interactions
Canagliflozin-metformin + Dienogest / estradiol valerate
Severity: Minor
Canagliflozin-metformin and Dienogest / estradiol valerate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined hormonal contraceptives can slightly impair glucose tolerance and may reduce the glycemic effect of antidiabetic drugs. The effect is usually small with modern low-dose products.
What this interaction means in plain words
Canagliflozin-metformin and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Hormonal effects on insulin sensitivity and carbohydrate metabolism may mildly oppose antidiabetic therapy.
What to do
Monitor glucose control after starting or stopping the hormonal product and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Canagliflozin-metformin with Dienogest / estradiol valerate?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combined hormonal contraceptives can slightly impair glucose tolerance and may reduce the glycemic effect of antidiabetic drugs. The effect is usually small with modern low-dose products.
How serious is the interaction between Canagliflozin-metformin and Dienogest / estradiol valerate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control after starting or stopping the hormonal product and adjust antidiabetic therapy if needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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