Drug interactions
Canagliflozin-metformin + Diltiazem
Severity: Minor
Canagliflozin-metformin and Diltiazem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers like diltiazem may modestly impair glucose tolerance, and in some patients reduce glycemic control on metformin. Diltiazem may also raise metformin exposure slightly. The clinical effect is generally small.
What this interaction means in plain words
Canagliflozin-metformin and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Diltiazem belongs to Cardiovascular.
Why it happens
Calcium channel blockade may reduce insulin secretion and peripheral insulin sensitivity.
What to do
Monitor blood glucose when starting or stopping diltiazem and adjust antidiabetic doses if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Canagliflozin-metformin with Diltiazem?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers like diltiazem may modestly impair glucose tolerance, and in some patients reduce glycemic control on metformin. Diltiazem may also raise metformin exposure slightly. The clinical effect is generally small.
How serious is the interaction between Canagliflozin-metformin and Diltiazem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping diltiazem and adjust antidiabetic doses if needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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