Drug interactions
Canagliflozin-metformin + Enalapril
Severity: Moderate
Canagliflozin-metformin and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance insulin sensitivity and occasionally cause hypoglycemia with antidiabetics. Together with canagliflozin they can also contribute to volume depletion, hypotension and acute kidney injury, which raises the risk of metformin accumulation.
What this interaction means in plain words
Canagliflozin-metformin and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Enalapril belongs to Cardiovascular.
Why it happens
ACE inhibition improves insulin sensitivity, and combined diuretic-like effects with canagliflozin can reduce renal perfusion.
What to do
Monitor blood glucose, blood pressure, renal function and potassium after starting or adjusting therapy. Hold the drugs during dehydrating illness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Canagliflozin-metformin with Enalapril?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance insulin sensitivity and occasionally cause hypoglycemia with antidiabetics. Together with canagliflozin they can also contribute to volume depletion, hypotension and acute kidney injury, which raises the risk of metformin accumulation.
How serious is the interaction between Canagliflozin-metformin and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, blood pressure, renal function and potassium after starting or adjusting therapy. Hold the drugs during dehydrating illness.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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