Drug interactions
Canagliflozin-metformin + Fosphenytoin
Severity: Moderate
Canagliflozin-metformin and Fosphenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin can inhibit insulin release and cause hyperglycemia, which may reduce antidiabetic effectiveness. Phenytoin also induces UGT enzymes and can lower canagliflozin exposure.
What this interaction means in plain words
Canagliflozin-metformin and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Fosphenytoin belongs to Central Nervous System.
Why it happens
Phenytoin suppresses insulin secretion and induces UGT enzymes that metabolize canagliflozin.
What to do
Monitor blood glucose when starting or stopping fosphenytoin and adjust antidiabetic therapy. Consider a higher canagliflozin dose if control is inadequate and eGFR allows.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Fosphenytoin?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin can inhibit insulin release and cause hyperglycemia, which may reduce antidiabetic effectiveness. Phenytoin also induces UGT enzymes and can lower canagliflozin exposure.
How serious is the interaction between Canagliflozin-metformin and Fosphenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fosphenytoin and adjust antidiabetic therapy. Consider a higher canagliflozin dose if control is inadequate and eGFR allows.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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